Efficacy and prognostic factors of androgen deprivation therapy combined with radiation therapy for prostate cancer

Evidence-based Complementary and Alternative Medicine Zeng S, Guan G, Qin Q, et al. | November 11, 2021

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Treatment of prostate cancer with androgen deprivation therapy (ADT) combined with radiation therapy provides a better survival benefit and this treatment strategy has a fairly good efficacy.

  • A retrospective analysis of clinical data of 94 prostate cancer patients treated in the Oncology Department of Xiangzhou People’s Hospital from January 2017 to January 2018, to assess the efficacy of ADT combined with radiation therapy for prostate cancer.

  • In the reference group, patients were only administered the radiotherapy, and on this basis, those in the combined group accepted ADT.

  • The combined group (ADT plus radiotherapy) exhibited significantly lower total prostate-specific antigen and vascular endothelial growth factor levels, significantly higher objective remission rate and disease control rate, and remarkably longer modified progression-free survival and overall survival after treatment, than the reference group.

  • Clinical prognosis of prostate cancer is impacted by factors such as the Gleason score of 8–10, positive lymphatic metastasis, and single radiotherapy.

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