Pregnancy outcomes in women with psoriatic arthritis with respect to presence and timing of antirheumatic treatment.
Arthritis & Rheumatology — Remaeus K, Johansson K, Granath F, et al. | October 22, 2021
In this Swedish nationwide register-based cohort study, pregnancy outcomes were examined in relation to antirheumatic treatment before and during pregnancy as a proxy of disease severity in PsA-pregnancies as compared with non-PsA-pregnancies.
Included were 921 PsA- pregnancies and 9,210 non-PSA-pregnancies (matched 1:10 on maternal age, year, and parity).
Relative to women with non-PsA-pregnancies, those with PsA-pregnancies were more frequently obese, more often smokers and had a diagnosis of pre-gestational hypertension and diabetes.
In comparison with non-PsA-pregnancies, those exposed to antirheumatic treatment during pregnancy, especially biologics, are mostly at increased risks of preterm birth and cesarean delivery.
Findings support providing special attention to first pregnancies given the influence of parity on the risk of preterm birth in PsA pregnancies.
During pregnancy, individualized monitoring should be done in women with PsA.
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