Predictive value of mean platelet volume for pulmonary embolism recurrence

LungAraz O, et al. | June 21, 2017

This study's plan was to assess whether mean platelet volume (MPV) and platelet distribution width (PDW) have utility as new predictive parameters for recurrence and mortality in pulmonary embolism. The outcomes suggested that MPV seems to be an indicator of recurrence in pulmonary embolism and may have utility in the prediction of recurrence. However, elevated MPV can also be used to predict mortality in pulmonary embolism.

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Methods

  • For the purpose of this study, four hundred forty patients with pulmonary embolism underwent computed tomography, Doppler ultrasonography, and echocardiography  before and at the end of treatment. 
  • In addition, thrombocyte count, MPV, PDW, and D-dimer parameters were assessed at the same time points.

Results

  • The results of this study showed that MPV and PDW were significantly higher in deceased patients (8.8 ± 1.2 fl and 17.4 ± 0.8) compared to surviving patients (7.7 ± 0.9 fl and 17 ± 0.9) (p < 0.0001).
  • It was also noted that initial MPV and PDW were significantly higher in patients with recurrence (8.4 ± 0.7 vs 7.6 ± 0.8 fl, p < 0.0001 and 17.3 ± 0.8 vs 16.9 ± 0.9, p = 0.002, respectively) than in patients without recurrence.
  • However, MPV was still higher in patients with recurrence compared to patients without recurrence (8.7 ± 0.5 and 7.5 ± 0.7 fl, respectively, p < 0.0001) at the end of treatment.
  • Findings revealed that MPV values over 8.05 fl at the end of treatment predicted recurrence with 91% sensitivity and 77% specificity.

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