IgG1 and IgG4 anti-CCP associate with shared epitope, whereas IgG2 anti-CCP associates with smoking in patients with recent-onset rheumatoid arthritis (the Swedish TIRA project)

Clinical and Experimental ImmunologyMartinsson K, et al. | November 29, 2016

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Researchers draw an inference which delineates different risk factor characteristics across the IgG anti–CCP subclasses, where IgG2 appears similar to IgA anti–CCP regarding the predominant association with smoking. In addition, IgG1 and IgG4 related more distinctly to the carriage of shared epitope (SE) genes.

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