A 12-year study evaluating the outcomes and predictors of mortality in critically ill cancer patients admitted with septic shock

BMC CancerAwad WB, Nazer L, Elfarr S, et al. | June 17, 2021

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This study was undertaken to investigate the outcomes and to identify predictors of mortality in cancer patients admitted to the intensive care unit (ICU) with septic shock. Researchers designed a retrospective study conducted at a medical-surgical oncologic ICU of a comprehensive cancer center. Between January 1, 2008 and December 31, 2019, Adult cancer patients admitted with septic shock were included. Predictors associated with ICU and hospital mortality were distinguished by performing univariate analysis and logistic regression. A total of 1408 patients were included during the study period (mean age was 56.8 ± 16.1 [SD] years and mean Acute Physiology and Chronic Health Evaluation [APACHE]II was 23.0 ± 7.91 [SD]). Hospital mortality was reported in about two-third of the patients in a relatively large cohort of patients with solid and hematological malignancies admitted to the ICU with septic shock. According to the findings, mechanical ventilation, APACHE II, thrombocytopenia, positive cultures, elevated bilirubin and lactic acid levels were significant predictors of mortality.

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