Thromboelastograph: A prognostic marker in sepsis with organ dysfunction without overt bleeding
Journal of Critical Care — Fibi Ninan K, Iyadurai R, Varghese JK, et al. | June 24, 2021
Given the frequent encounter with coagulation abnormalities in patients with sepsis with organ dysfunction even in the absence of overt bleeding, researchers herein examined if abnormalities in thromboelastogram (TEG) are linked with mortality in cases with severe sepsis without overt bleeding. Based on admission TEG parameters (R time, K time, Maximum amplitude (MA), α angle), categorization of patients was done in this prospective study, as those with normal coagulation, hypercoagulable or hypercoagulable state. Mortality was observed in correlation with prolonged R time and reduced alpha angle in patients with hypocoagulable state. Patients requiring transfusion had significantly different K time, α angle and MA. Overall observations support the correlation of thromboelastogram with severity of organ dysfunction and subsequent transfusion requirement in these patients. They suggest a possible utility of thromboelastogram in the prognostication of patients with sepsis without overt bleeding.
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