Presepsin as a predictor of septic shock in patients with urinary tract infection
BMC Urology — Sekine Y, Kotani K, Oka D, et al. | October 15, 2021
Findings demonstrate that presepsin could afford a good marker for diagnosing septic shock based on admission data in patients suffering from urinary tract infections (UTI).
This study included 50 patients with UTI who were admitted to Gunma university hospital from April 2014 to December 2016.
Patients were split into two groups: with (n = 11) or without (n = 39) septic shock on the enrollment day, and with (n = 7) or without (n = 43) sepsis on the fifth day, respectively.
In multivariate logistic regression analysis, presepsin (≥ 500 pg/ml) was revealed as an independent risk factor for septic shock.
For septic shock diagnosis, presepsin yielded an area under the curve (AUC) of 0.881 in receiver operating characteristics (ROC) curve analysis [vs 0.690, 0.583, and 0.527 for procalcitonin (PCT), C-reactive protein (CRP) and white blood cell (WBC), respectively].
For diagnosing sepsis on the fifth day, ROC curve showed an AUC of 0.837 for PCT (vs 0.817, 0.811, and 0.802 for presepsin, CRP, and WBC, respectively).