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Presepsin as a predictor of septic shock in patients with urinary tract infection

BMC UrologySekine Y, Kotani K, Oka D, et al. | October 15, 2021

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Findings demonstrate that presepsin could afford a good marker for diagnosing septic shock based on admission data in patients suffering from urinary tract infections (UTI).

  • This study included 50 patients with UTI who were admitted to Gunma university hospital from April 2014 to December 2016.

  • Patients were split into two groups: with (n = 11) or without (n = 39) septic shock on the enrollment day, and with (n = 7) or without (n = 43) sepsis on the fifth day, respectively.

  • In multivariate logistic regression analysis, presepsin (≥ 500 pg/ml) was revealed as an independent risk factor for septic shock.

  • For septic shock diagnosis, presepsin yielded an area under the curve (AUC) of 0.881 in receiver operating characteristics (ROC) curve analysis [vs 0.690, 0.583, and 0.527 for procalcitonin (PCT), C-reactive protein (CRP) and white blood cell (WBC), respectively].

  • For diagnosing sepsis on the fifth day, ROC curve showed an AUC of 0.837 for PCT (vs 0.817, 0.811, and 0.802 for presepsin, CRP, and WBC, respectively).

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