Comparative accuracy of pleural fluid unstimulated interferon-gamma and adenosine deaminase for diagnosing pleural tuberculosis: A systematic review and meta-analysis

PLoS Neglected Tropical DiseasesAggarwal AN, Agarwal R, Dhooria S, et al. | June 25, 2021

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This study sought to correlate diagnostic accuracy of pleural fluid adenosine deaminase (ADA) and interferon-gamma (IFN-γ) in diagnosing tuberculous pleural effusion (TPE) through systematic review and comparative meta-analysis. Researchers tested PubMed and Embase databases to identify studies providing paired data for sensitivity and specificity of both pleural fluid ADA and IFN-γ for diagnosing TPE. They applied hierarchical summary receiver operating characteristic (HSROC) plots and HSROC meta-regression to model individual and comparative diagnostic performance of the two tests. They examined 376 citations and included 45 datasets from 44 publications (4974 patients). The data illustrates that for diagnosis of TPE, pleural fluid IFN-γ estimation has better diagnostic accuracy than ADA estimation.

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