Risk factors for recurrent urinary tract infection in children with neurogenic bladder following clean intermittent catheterization

UrologyJiang M, Deng J, Zhou G, et al. | January 12, 2022


In a pediatric population with neurogenic bladder (NB), the factors that could be directly associated with recurrent urinary tract infections (UTIs) include older age, high level of spinal cord lesions, long duration of NB, vesicoureteral reflux (VUR), increased bladder wall thickness (BWT), and low bladder compliance. Higher susceptibility to chronic renal insufficiency was seen after recurrent UTIs in children with NB.

  • In 327 children (age 9-151 months) who had clean intermittent catheterization, the risk factors for recurrent UTIs were retrospectively examined during a 5-year period.

  • Recurrent UTIs (>1.0 UTI/study-year) and episodic UTIs (≤1.0 UTI/study-year) occurred in 79 (24.2%) and 248 (75.8%) patients, respectively.

  • Following significant factors for recurrent UTIs were revealed in univariate and multivariate analyses: older age, lumbar level lesions, long duration of NB, presence of VUR, increased BWT, and low bladder compliance.

  • In univariate but not in multivariate analysis, bladder trabeculation was shown to be linked with recurrent UTIs.

  • A diagnosis of chronic renal insufficiency was made during follow-up in 31 (39.2%) and 29 patients (11.7%) in the recurrent and episodic UTI groups, respectively.

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