Humoral immune response in hematooncological patients and health care workers who received SARS-CoV-2 vaccinations

JAMAMair MJ, Berger JM, Berghoff AS, et al. | January 24, 2022


Researchers aimed at assessing antibodies development in patients with cancer following SARS-CoV-2 vaccination and comparing their antibody levels with those of healthcare workers.

  • A total of 901 samples from 595 patients with hematooncological diseases and a control group of health care workers were assessed in this cohort study.

  • There could be detection of anti–SARS-CoV-2 spike antibodies after full immunization, although lower antibody levels were observed in patients than in health care workers.

  • However, impaired seroconversion occurs in specific subgroups, such as patients who received B-cell–targeting therapy.

  • These findings emphasize the necessity for dedicated vaccination trials in patients with cancer.

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