Association between mRNA vaccination and COVID-19 hospitalization and disease severity

JAMATenforde MW, Self WH, Adams K, et al. | November 29, 2021


Researchers sought to determine if vaccination with mRNA COVID-19 vaccines—mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech)—is associated with reduced COVID-19 hospitalization, and, among patients hospitalized with COVID-19, with reduction in the progression to critical disease.

  • A case-control study of 4,513 hospitalized adults in 18 US states; these comprised 1,983 case patients with COVID-19 and 2,530 controls without COVID-19.

  • For full vaccination with an authorized or approved mRNA COVID-19 vaccine, hospitalization for a COVID-19 diagnosis compared with an alternative diagnosis was linked with an adjusted odds ratio (aOR) of 0.15.

  • For full vaccination, progression to death or invasive mechanical ventilation was linked with an aOR of 0.33 among adults hospitalized for COVID-19.

  • Overall findings suggest that patients with COVID-19 hospitalization and with disease progression are significantly less likely to have received prior vaccination with an mRNA COVID-19 vaccine, this is consistent with risk reduction among vaccine breakthrough infections.

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