Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
Thrombosis Research — Skille H, Paulsen B, Hveem K, et al. | July 02, 2021
Researchers sought to determine the effect of individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) on VTE risk in occult cancer. From the Scandinavian Thrombosis and Cancer Cohort (1993–2012), they sampled cases with incident VTE (n = 1,566) and a subcohort (n = 14,537). Genotyping of five single nucleotide polymorphisms previously described in a GRS was done: ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865) and F11 (rs2036914). Among 1,817 individuals with development of occult cancer, 93 experienced a VTE. Findings revealed no correlation of prothrombotic SNPs with VTE risk in occult cancer. More prothrombotic cancer types and metastasis were recorded among occult cancer patients with VTE. In aggressive occult cancers, the prothrombotic state probably supersedes the effect of genotypes.
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