Estimated US infection- and vaccine-induced SARS-CoV-2 seroprevalence based on blood donations, July 2020-May 2021
JAMA — Jones JM, Stone M, Sulaeman H, et al. | October 15, 2021
Based on blood donations in the US from July 2020 through May 2021, trends in SARS-CoV-2 seroprevalence related to infection and vaccination were investigated in the US population.
During July 2020 through May 2021, a repeated cross-sectional study was conducted each month, including 1,443,519 blood donation specimens from a catchment area representing 74% of the US population.
There appeared an increase in estimated SARS-CoV-2 seroprevalence weighted for differences between the study sample and general population from 3.5% in July 2020 to 20.2% for infection-induced antibodies and 83.3% for combined infection- and vaccine-induced antibodies in May 2021.
Differences in seroprevalence were identified by age, race and ethnicity, and geographic region of residence, but modification in these differences occurred over the course of the study.
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