Effect of 12 mg vs 6 mg of dexamethasone on the number of days alive without life support in adults with COVID-19 and severe hypoxemia: The COVID STEROID 2 randomized trial

JAMAThe COVID STEROID 2 Trial Group, et al. | October 25, 2021

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Researchers conducted a multicenter, randomized clinical trial examining how 12 mg vs 6 mg of dexamethasone affects the number of days alive without life support at 28 days in patients with COVID-19 and severe hypoxemia.

  • A total of 1,000 adults with confirmed COVID-19 requiring at least 10 L/min of oxygen or mechanical ventilation, were included.

  • Treatment with 12 mg/d of dexamethasone was linked with 22.0 days alive without life support vs 20.5 days in those receiving 6 mg/d of dexamethasone.

  • Overall, 12 mg of dexamethasone did not link with statistically significant reduction in the number of days alive without life support at 28 days when compared with 6 mg of dexamethasone.

Read the full article on JAMA

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