Overall and cause-specific hospitalization and death after COVID-19 hospitalization in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform

PLoS MedicineBhaskaran K, Rentsch CT, Hickman G, et al. | February 03, 2022

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Researchers investigated if people who have been in hospital with COVID-19 are at higher risks of hospital admission and death, either overall or for specific illnesses, compared with people in the general population, and people who have been hospitalized with influenza.

  • In this cohort study, people who had hospitalized with COVID-19 (n = 24,673) were compared with people with similar demographic characteristics in the 2019 general population (n = 123,362), and people who had been hospitalized with influenza in 2017 to 2019 (n = 16,058) with respect to their risks of hospitalization and death, overall and for a range of specific causes.

  • People who had had a COVID-19 hospitalization were more than twice as likely to be rehospitalized or die more than a week after discharge, with greater risks overall and for a range of specific causes when compared with people in the general population.

  • Broadly similar or lower risk of several outcomes was recorded for COVID-19 patients compared with influenza patients, but there appeared higher risk of death overall, readmissions or death due to the initial infection, and dementia death in COVID-19 patients.

  • Increased monitoring of patients in the months following hospital discharge, and greater awareness among patients and clinicians of potential problems might minimize or mitigate the risks.

Read the full article on PLoS Medicine

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