Efficacy of Wolbachia-infected mosquito deployments for the control of dengue
New England Journal of Medicine — Utarini A, Indriani C, Ahmad RA, et al. | June 11, 2021
In view of the reports of less susceptibility of Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia pipientis relative to wild-type A. aegypti to dengue virus infection, researchers herein undertook a cluster-randomized trial involving releases of wMel-infected A. aegypti mosquitoes for the control of dengue in Yogyakarta, Indonesia. Twelve geographic clusters were randomly assigned to receive deployments of wMel-infected A. aegypti (intervention clusters) and 12 clusters to receive no deployments (control clusters). They enrolled 8,144 participants after successful introgression of wMel into the intervention clusters; 3,721 lived in intervention clusters, and 4,423 lived in control clusters. Using a test-negative design, they identified introgression of wMel into A. aegypti populations as effective in lowering the incidence of symptomatic dengue and resulting in fewer hospitalizations for dengue among the participants.