Efficacy of Wolbachia-infected mosquito deployments for the control of dengue

New England Journal of MedicineUtarini A, Indriani C, Ahmad RA, et al. | June 11, 2021

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In view of the reports of less susceptibility of Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia pipientis relative to wild-type A. aegypti to dengue virus infection, researchers herein undertook a cluster-randomized trial involving releases of wMel-infected A. aegypti mosquitoes for the control of dengue in Yogyakarta, Indonesia. Twelve geographic clusters were randomly assigned to receive deployments of wMel-infected A. aegypti (intervention clusters) and 12 clusters to receive no deployments (control clusters). They enrolled 8,144 participants after successful introgression of wMel into the intervention clusters; 3,721 lived in intervention clusters, and 4,423 lived in control clusters. Using a test-negative design, they identified introgression of wMel into A. aegypti populations as effective in lowering the incidence of symptomatic dengue and resulting in fewer hospitalizations for dengue among the participants.

Read the full article on New England Journal of Medicine

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