Implications of COVID-19 in high burden countries for HIV/TB: A systematic review of evidence

BMC Infectious DiseasesTamuzi JL, Ayele BT, Shumba CS, et al. | October 12, 2020

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This research was undertaken to examine different studies on SARS-CoV, MERS-CoV or COVID-19 associated with HIV/TB co-infection or only TB, to understand the interactions between HIV, TB, and COVID-19 and its implications on the burden of the COVID-19 among HIV/TB co-infected or TB patients, screening algorithm and clinical management. Researchers performed an electronic search of potentially eligible studies published in English in the Cochrane Controlled Register of Trials, PubMed, Medrxiv, Google scholar, and Clinical Trials Registry databases. They enrolled case studies, case series, and observational studies published between January 2002 and July 2020 in which SARS-CoV, MERS-CoV, and COVID-19 co-infected to HIV/TB or TB in adults. The data revealed that TB was found to be a risk factor for COVID-19 both in terms of severity and mortality irrespective of HIV status. It was recorded that structured diagnostic algorithms and clinical management are implied to enhance COVID-19/HIV/TB or COVID-19/TB co-infections outcomes.

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