Discontinuation of antihypertensive medications on the outcome of hospitalized patients with severe acute respiratory syndrome-coronavirus 2

HypertensionSingh S, Offringa-Hup AK, Logtenberg SJJ, et al. | June 11, 2021

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A meta-analysis was conducted to explore the possible detrimental effects of renin-angiotensin-aldosterone system inhibitors (RAASi) on the severity of (SARS-CoV-2) infection demonstrated that ambulatory use of RAASi, by hospitalized patients, has a neutral effect. The effect of discontinuation of antihypertensive medications in hospitalized patients with SARS-CoV-2 was tested. Researchers carried out a retrospective observational study including a total of 1,584 hospitalized patients with SARS-CoV-2 from 10 participating hospitals in the Netherlands. It was shown that discontinuation of at-home ACE inhibitor, angiotensin receptor blockers, or β-blocker in patients hospitalized for a SARS-CoV-2 infection was correlated with an elevated risk of dying, whereas discontinuation of calcium channel blockers and diuretics was not.

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