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Aspirin for Treatment of Multiple Sclerosis-Related Fatigue

Sponsored by Mayo Clinic

Phase Quota
Phase 3

The purpose of this study is to determine whether aspirin is effective for treatment of fatigue caused by multiple sclerosis (MS).

Study Start Date: March 2007

Estimated Completion Date: May 2014

Specialties: Psychiatry: Psychotherapy/analysis Neurology: Demyelinating Disorders,Neuro/Psych pharmacology Pharmacy: Neuro/Psych pharmacology

Interventions

  • Drug: Aspirin

Inclusion criteria

  • Confirmed relapsing-remitting or secondary progressive multiple sclerosis
  • Ambulatory for distance of at least 100 m without gait assistance
  • Persistent fatigue for at least 8 weeks that is not attributable to causes other than MS, and
  • Will be able to complete questionnaires and cognitive testing

Exclusion criteria

  • Other evident causes for fatigue
  • Recent MS disease activity or specific changes in MS therapy
  • Current use of ASA or other NSAIDs
  • Use of CNS stimulants
  • Use of medications that contraindicate the use of ASA, ASA allergy or sensitivity
  • History of peptic ulcer disease or GI bleed
  • Alcohol abuse
  • Pregnancy, and
  • Laboratory abnormalities

Study Locations And Contact Information

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