Breast cancer risk among postmenopausal women increases with increasing body mass index (BMI). It was estimated that there is a 3% increase in risk per 1 kg/m2 increase in BMI. The mechanism for the association between obesity and breast cancer risk is not established, but it may result, at least in part, from an increase in the serum concentration of bioavailable estradiol, which results from both an increase in the production of estrogens by aromatase in the adipose tissue and a decrease in the serum concentration of sex hormone–binding globulin.
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