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Deep Brain Stimulation for Treatment Resistant Depression

Sponsored by Emory University

Phase Quota
Phase 1

The purpose of the proposed study is to evaluate the safety, feasibility and efficacy of chronic, high frequency stimulation of the subgenual cingulate white matter (Cg25WM) using the ANS Totally Implantable Deep Brain Stimulation System as an adjunctive treatment for severe treatment-refractory Major Depression in twenty TRD patients, and to investigate potential mechanisms of action of this intervention.

Study Start Date: September 2006

Estimated Completion Date: September 2018

Specialties: Psychiatry: Mood Disorders

Interventions

  • Device: Deep Brain Stimulator, implantable

Inclusion criteria

  • Age 18-70 years old.
  • Currently insured or receiving Medicare.
  • Ability to provide written informed consent.
  • Diagnosis of a Major Depressive Episode or Bipolar Type II - current episode depressed
  • Current episode duration of at least 1 year
  • Failure to respond to a minimum of four different antidepressant treatments.
  • Failure or intolerance of an adequate course of electroconvulsive therapy (ECT) during any episode.
  • All patients must have an established outpatient psychiatrist and be willing to sign a written release to allow study investigators to give and receive information from this psychiatrist
  • Willing to temporarily relocate to the Atlanta area for at least 3-4 months and return for all required follow-up visits

Exclusion criteria

Study Locations And Contact Information

  • Emory University School of Medicine, Atlanta Georgia
  • Emory University School of Medicine, Atlanta Georgia
  • Emory University School of Medicine, Atlanta Georgia

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