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Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)

Sponsored by Washington University School of Medicine

Phase Quota
Phase N/A

The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).

Study Start Date: December 2008

Estimated Completion Date: December 2015

Specialties: Internal Medicine: Neurology Psychiatry: Anxiety Neurology: Movement Disorders Physician Assistant: Neurology

Interventions

No interventions cited

Inclusion criteria

Inclusion Criteria for STN-DBS subjects:

  • Age 40 or older
  • DBS STN Surgery in past 2 to 36 months
  • Ability to tolerate turning off Stimulators
  • Ability to read and comprehend questions
  • English speaking

Inclusion Criteria for Control subject:

  • Age 40 or older
  • Ability to read and comprehend questions
  • English speaking

Exclusion criteria

Exclusion Criteria for STN-DBS subjects:

  • Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
  • Clinically determined Dementia ( Most recent MMSE score of >24)

Exclusion Criteria for Control subject:

  • Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
  • Clinically determined Dementia ( Most recent MMSE score of >24)
  • Plans to have DBS STN surgery in the next 24 months

Study Locations And Contact Information

  • Washington University School of Medicine, St. Louis Missouri
  • University of Cincinnati Movement Disorder Center, Cincinnati Ohio
  • Washington University School of Medicine, St. Louis Missouri

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