Advertisement

Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial

Sponsored by University of Pittsburgh

Phase Quota
Phase 3

The purpose of this study is to understand the efficacy of light therapy for bipolar depression.

Study Start Date: May 2009

Estimated Completion Date: February 2015

Specialties: Internal Medicine: Psychiatry Nursing: Mental Health Psychiatry: Anxiety Family Medicine: Psychiatry Physician Assistant: Psychiatry

Interventions

  • Device: active light therapy unit
  • Device: Inactive light therapy unit

Inclusion criteria

  • Ages 18-65 years
  • DSM-IV Criteria BD I or II depressive episode,
  • SIGH-ADS >20; duration >2 weeks
  • Stable dose antidepressant drug >8 weeks with concurrent antimanic drug
  • Controlled thyroid disease
  • Subjects with preexisting eye diseases will be included
  • Able to provide informed consent
  • Stable minimum dose antimanic drug >4weeks: lithium 0.5 mEq/L, divalproex Na 50 mcg/mL, olanzapine 5mg daily, carbamazepine 4mg/L; lamotrigine 100mg daily, risperidone 2mg daily, quetiapine 400 mg daily, ziprasidone 10 mg bid, and aripiprazole 5 mg qd
  • Stable unchanged psychotherapy for >16weeks

Exclusion criteria

  • The following eye diseases: retinal disease, cataract surgery and lens removal, macular degeneration,
  • Taking photosensitizing drugs such as phenothiazines (chlorpromazine), antimalarial drugs, melatonin and hypericum
  • Acute psychosis (DSM-IV Criteria)
  • Rapid cycling in the past 1 year
  • Obsessive compulsive disorder
  • Alcohol or substance abuse or dependence in the past 6 months
  • MRS>5
  • Recent history of a suicide attempt (3 months) or active suicidal Ideation (SIGHADS item H11 >2)
  • Beta-adrenergic blockers, exogenous melatonin, chronic NSAIDS

Study Locations And Contact Information

  • University of Pittsburgh Western Psychiatric Institute and Clinic, Pittsburgh Pennsylvania
  • University of Pittsburgh, Pittsburgh Pennsylvania

Feature this Clinical Trial

Get your trial in front of 1000s of physicians and patients.
Visit ClinicalTrialsLocator.com to find out how you can feature this clinical trial.

Advertisement